Fall 2009

Executive Editor:
Contributing Editor:
Dr. Francis Cucinotta
Kay Nute

In this issue

NASA NRA and NSCOR Grants Announced

NASA and its Space Radiation Program have announced the awards of NASA Specialized Center of Research (NSCOR) and NASA Research Award (NRA) grants.

NSCOR Awards
An NSCOR consists of a team of investigators who have complementary skills and who work together to solve a closely focused set of research questions.  These NSCOR awards (Solicitation NSCOR NNJ08ZSA003N)  are for five years. The 2009 NSCOR teams will be led by: 

Mary Helen Barcellos-Hoff, New York University School of Medicine, New York NY
“The contribution of non-targeted effects in HZE cancer risk”

Albert Fornace, Georgetown University, Washington D.C.
“Space radiation and intestinal tumorigenesis: risk assessment and countermeasure development”

Gregory Nelson, Loma Linda University, Loma Linda CA
“Charged particle radiation and resultant oxidative stress elicit deleterious functional changes in the central nervous system”

Robert Ullrich, University of Texas Medical Branch, Galveston TX
“NASA specialized center of research on radiation carcinogenesis”

NRA Awards
NASA’s Space Radiation Program has selected individual investigator awards for Ground-Based Studies in Space Radiobiology (Solicitation NNJ09ZSA001N). Recipients of the awards, ranging in duration from one to four years, and the titles of their projects follow. Jaroslaw Dziegielewski, an alumni of the NASA Space Radiation Summer School, has become its first graduate named as a principal investigator for a NASA grant!  Also among the new grantees are three persons who participated in the NASA Space Radiation Summer School as auditors:  Peter Grabham, Janice Huff, and Marianne Sowa. 

Jack Bergman, McLean Hospital, Boston MA
“Long term effects of space radiation in nonhuman primates”

Sandeep Burma, University of Texas Southwestern Medical Center at Dallas, Dallas TX
“Gliomagenesis and radiation: A sensitive model system to evaluate the tumorigenic potential of HZE particles”

Jaroslaw Dziegielewski, University of Virginia, Charlottesville VA
“Effects of prolonged exposure to space radiation on carcinogenesis and neuroendocrine differentiation in human prostate models”

Peter Grabham, Columbia University, New York NY
“Development and use of human 3-Dimensional tissue culture models for the study of space radiation effects on the central nervous system”

Lora Green, Loma Linda University, Loma Linda CA
“Mechanisms of low dose HZE alteration of neuronal-astrocytic coupling: The role of purinergic receptors and calcium signaling”

Janice Huff, Universities Space Research Association, Houston TX
“Impact of radiation quality on cancer processes in 2D and 3D esophageal cell models”

Dennis Kucik, University of Alabama at Birmingham, Birmingham AL
“Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis”

Howard Liber, Colorado State University, Ft. Collins CO
“Radiation quality and the relationship between induced telomere dysfunction and mutagenesis”

Mamta Naidu, Brookhaven National Laboratory, Upton NY
“High LET-radiation induced DNA repair mechanisms in oligodendrocyte progenitor cells (OPC) in vitro and in vivo”

Marianne Sowa, Battelle Memorial Institute, Pacific Northwest Laboratory. Richland WA
“Integrated experimental and computational study of radiation induced matrix remodeling in a human skin equivalent”

Mitchell Turker, Oregon Health and Science University, Portland OR
“The relation between mutagenesis and genomic instability after particle exposure in vivo”

Paul Yaswen, Lawrence Berkeley National Laboratory, Berkeley CA
“Epigenetic effects of radiation on epithelial cell self-renewal”

Abstracts for the grantees may be viewed in the Advanced Capabilities Division Research and Technology Task Book online database of research projects.

The research to be supported by these grants will seek to reduce the uncertainties in risk predictions for cancer radiation risks, to provide the necessary data and knowledge to develop risk projection models for central nervous system (CNS) and other degenerative tissue risks, and significantly advance the understanding of the mechanisms of biological damage that underlies radiation health risks.  The research is also expected to provide a substantial contribution to the scientific basis for eventual development of biological countermeasures to these risks as appropriate.

Space Radiation Investigators Remembered

Caught in a lively scientific discussion are (from left) John Ainsworth, Edward L. Alpen, and Aloke Chatterjee (sadly, all now deceased).We are sad to report the passing, within two weeks of each other, of John Ainsworth and Aloke Chatterjee.

Earl John Ainsworth, Jr. passed away July 5, 2009 in Pleasanton, California. He grew up in New Castle, Ind., and Indianapolis, and was a graduate of Shortridge High School and Butler University in Indianapolis. He earned Masters and Ph.D degrees from Brown University in Providence, R.I. and enjoyed a 39-year career as a research scientist and laboratory administrator, focusing on the fields of radiation biology, nuclear physics and biochemistry.

John worked at the Naval Radiological Defense Laboratory in San Francisco, Argonne National Laboratory in Lemont, Ill., Lawrence Berkeley National Laboratory in Berkeley and the Armed Forced Radiation Research Institute in Bethesda, Md., where he served as scientific director. While in Berkeley, he was awarded a Fogarty Senior International Fellowship by the National Institutes of Health including a one-year sabbatical to an institute in Darmstadt, Germany, where he and his wife Carolyn enjoyed living and traveling throughout Europe. Though he retired in 1998, he was an eager participant in the 2005 NASA Space Radiation Investigators’ Workshop held in Port Jefferson, New York. John Ainsworth made major contributions to the understanding of acute effects, cancer, cataracts, and normal damage risks from heavy ions and neutrons.

Aloke Chatterjee, a major contributor to radiation research in general, and to space radiation biology in particular, passed away June 20, 2009 at his home in Clayton, California.  Aloke was born in Kolkata, India, and obtained his undergraduate degrees at the University of Delhi. In 1966 he emigrated to the United States to study at Notre Dame University, where he obtained his doctorate in Chemical Physics in 1970.  After his graduation, Aloke joined the radiation research group headed by Cornelius Tobias at Lawrence Berkeley National Laboratory (Berkeley Lab), from where he retired after a distinguished scientific and administrative career Among his major contributions a theory of radiation chemical yields in the track of charged particles, developed with John Magee, popularizing the notion of track core and penumbra as approximations useful to describe different chemical reaction regimes around the track of a charged particle.

Edward L. Alpen, photographed with Ainsworth and Chatterjee, passed away in 2006, leaving a considerable legacy to the space radiation community.  During his lengthy career, he served at the US Naval Radiation Defense Laboratory, the Pacific Northwest National Laboratory, the Lawrence Berkeley National Laboratory, and the University of California Berkeley. His principal areas of research were experimental radiotherapy with charged particle beams and neutrons, radiation biophysics and medical physics, radiation, carcinogenesis, non-stochastic late effects in organ systems, and cellular radiation biology. He served on many national committees including five committees of the National Council of Radiation Protection (NCRP) that reported on topics ranging from the response to nuclear attacks to guidance on NASA astronaut safety to the biological and health effects of radiofrequency radiation (NCRP Report number 86).

The Health Risks of Extraterrestrial Environments (THREE) Launches

THREE – The Health Risks of Extraterrestrial Environments has been launched!  The goal is for this “encyclopedia” to serve as a central repository for information about space radiation. THREE is not meant to be a scientific journal; rather, its purpose is to serve as a jumping off point for persons interested in learning more about the topic.

Thus far, content on THREE consists of articles on the basic concepts of space radiation, radiation measurements, radiation dosimetry, radiation chemistry, and radiation risk management. There are also numerous slides in flash format that were presented to students at the NASA Space Radiation Summer School. These slides cover topics such as the space radiation environment, physics topics, biological responses to radiation, DNA damage and repair, radiation health effects, and microgravity effects.

We continue to seek articles that will be reviewed by an Editorial Board prior to their posting. For more information about submitting an article, please send an email to info@dsls.usra.edu.

Dispatches from the 20th Annual Space Radiation Investigators’ Workshop

Collage of images photos from the 20th Annual Space Radiation Investigators' WorkshopThe Heavy Ions in Therapy and Space Symposium, July 6–10, 2009, in Cologne, Germany, attracted nearly 300 registrants to discuss the effects of heavy ions on biological systems.

Sponsored by NASA, ESA, DLR, and the Cologne Chamber of Commerce and Industry, the Symposium included the 20th Annual NASA Space Radiation Health Investigators’ Workshop (SRHIW), the 12th Workshop on Ion Beam in Biology and Medicine (IBABM), the 5th International Workshop on Space Radiation Research (IWSRR), and the 1st ESA Space Radiation Investigators’ Meeting (ESRAD). 

The invited talks, plenary talks, and poster sessions encompassed a wide range of topics:

  • Cell and tissue radiobiology
  • DNA damage and repair
  • Signaling and pathways in cell biology
  • Late effects of heavy ions
  • Individual radiosensitivity
  • Bystander effects
  • Heavy ion carcinogenesis
  • CNS damage
  • Countermeasures
  • Dosimetry in space
  • Treatment planning
  • Medical physics
  • Clinical results – studies and status reports on treatment
  • Beam production and dose delivery methods
  • Quality assurance and robotics

Awards were presented at the Symposium for contributions by graduate students and postdoctoral fellows. Postdoctoral investigator Zarana Patel, a Universities Space Research Association Division of Space Life Sciences scientist in the NASA Johnson Space Center Space Radiation Laboratory, won first place in the Student Poster Contest. Her poster was entitled “Esophageal Epithelial Cells Exhibit Increased Migration and Invasion in Two- and Three-Dimensional Cell Culture Models as Triggered by Irradiated Fibroblasts.”  Postdoctoral investigator Chiara La Tessa of the Biophysics Division of GSI received first place in the Student Presentation Contest. Her talk was titled “Simulation of the ALTEA-Space Experiment with PHITS Monte Carlo Code.”  Each first place award received a cash award of 600 Euros.

 

Photo of Chiara La Tessa, winner of the Symposium Student Contest and photo of Janice Huff, Christine Cucinotta, and Zarana Patel a the banquet.

Announcing Dates for the 21st Annual Space Radiation Investigators’ Workshop and 4th International Space Radiation Systems Biology Workshop

NASA has announced the dates and venue for the 21st Annual Space Radiation Investigators’ Workshop.

Returning to the venue of the 15th and 16th Annual Workshops, the 21st Annual Workshop will be held May 17-19, 2010 in Port Jefferson, New York.  This location is near the NASA Space Radiation Laboratory at the Brookhaven National Laboratory in Brookhaven, New York.

The Fourth International Space Radiation Systems Biology Workshop will follow in New York City at New York University from May 20-22, 2010.

 

Updates to MICROS 2009 – 15th International Symposium on Microdosimetry

Verona ItalyUpdates to MICROS 2009, the 15th International symposium on Microdosimetry may be found at the Symposium website.

Invited, Oral, and Poster presentations, as well as Refresher courses, will be offered on the following main topics:

  • Physical, chemical and biological aspects of radiation transport and particle track formation for various radiation fields including space radiation environments.
  • Processes leading to and repair of molecular, cellular, and tissue radiation damage.
  • Computational biology for radiation induced modifications of biological targets at cellular, tissue and organism levels, including radiation carcinogenesis.
  • Novel techniques of radiation detection, dosimetry and microdosimetry.
  • Advances in mcirobeam technology.
  • Non-linear phenomena at low-doses such as radiation-induced bystander effects, genomic instability, adaptive response and hyper-radiosensitivity.
  • Advances in radiation therapy, including hadron therapy.
  • Dosimetry for incorporated radionuclides.
  • Radiation risk assessment.

 

SRP Software Releases

Three new software packages are currently in development to improve the assessment of risks to astronauts from harmful space radiation. The NASA Baryon Transport code (BRYNTRN) and the Acute Radiation Risk (ARR) code have been combined into a user friendly Graphical User Interface (GUI) to predict organ doses and prodromal risks for major solar particle events. The Code named ARRBOD went through Beta testing during the summer of 2009, and is scheduled for a December 2009 release. 
To assist engineers and radiation shielding designers in the shielding analysis of complex spacecraft structures, scientists in NASA’s Space Radiation Program have developed a software tool to perform complex ray tracing algorithms to represent mass distributions for spacecraft with hundreds to thousands of parts. The code for the toolkit named “Fishbowl” runs in the ProE engineering CAD environment. A Users Guide has been released as a NASA Technical Publication "The Use of Pro/ENGINEER CAD Software and Fishbowl Toolkit in Ray-tracing Analysis".

 

Caption: This graphic illustrates the directional dose profile on a unit sphere inside a lunar transfer vehicle prototype using the Space Radiation Program ProE ray tracer and the ARRBOD code.


Caption: This graphic illustrates the directional dose profile on a unit sphere inside a lunar transfer vehicle prototype using the Space Radiation Program ProE ray tracer and the ARRBOD code.

Caption: The new computer program GERMCode_NSRL (left panel) will allow investigators to simulate heavy ions beams including energy loss (LET), nuclear interactions, track structures, and Bragg curves (right panel) and to integrate biological response models with physical descriptions of heavy ion beams.

Caption: The new computer program GERMCode_NSRL (left panel) will allow investigators to simulate heavy ions beams including energy loss (LET), nuclear interactions, track structures, and Bragg curves (right panel) and to integrate biological response models with physical descriptions of heavy ion beams.

The latest addition to the NASA Space Radiation Program suite of software is the GCR Event Based Risk Model (GERMCode).  The initial version of the software running on a 32-bit Windows platform will support modeling of data from the NASA Space Radiation Laboratory (NSRL).  A future version, GERMCode_Mars, will simulate the GCR risks for Mars missions. The GERMCode_NSRL will provide scientists participating in experiments at NSRL or interpreting data from NSRL experiments, the ability to model the NSRL beam line, to model shielding of samples and sample holders, and to estimate basic physical parameters and expected radiobiological responses of those experiments. A beta version of GERMCode_NRSL will be released in the fall 2009.

These software packages are being developed by personnel in the NASA Space Radiation Program and their contractors.


Space Radiation Spotlight on Kerry O’Banion

Kerry O'Banion, M.D., Ph.D.The son of two educators, Kerry O’Banion has always adopted a broad view in his scientific pursuits.  As an undergraduate at the University of Illinois in Urbana-Champaign, he investigated pair bonding behavior in common prairie voles, but chose Microbiology for his PhD work because of the promise of immersing himself in molecular biology. Indeed, at the same time he was learning about human pathophysiology and how to do a proper neurological examination as an MD-PhD trainee in the nascent Medical Scholars Program, also at the University of Illinois in Urbana-Champaign, Kerry entertained working with Carl Woese, who had established the existence of a new kingdom of organisms (Archaea) by sequencing rRNA.  Ultimately Kerry carried out his thesis work with Manfred Reichmann in Microbiology and John Sundberg in the Department of Veterinary Pathobiology to characterize and clone novel animal papillomaviruses.  All together, he cloned viruses from six animal species and witnessed at national and international conferences the recognition that oncogenic human papillomaviruses caused cervical and other epithelial cancers.

Upon completion of his MD and PhD degrees in 1987, O’Banion made the decision to not pursue residency training, and instead accepted a post-doctoral position in the Departments of Medicine and Biochemistry with Donald Young at the University of Rochester. There he worked extensively with large format (“giant”) two-dimensional protein gels (the term “proteinomics” had not yet been coined) to characterize papillomaviral-host cell interactions and glucocorticoid regulated genes in the context of cell transformation.  Following up on earlier studies in the laboratory that had identified a highly regulated cyclooxygenase and working with Virginia Winn, a gifted MD-PhD student, Kerry cloned and sequenced cyclooxygenase-2 (COX-2). More importantly, the Rochester team identified COX-2 as the regulated isoforms critical in inflammation and went on to create cell lines for drug screening and file a patent for the development of COX-2 inhibitors to treat inflammation.  Ultimately the patent was not upheld in a widely publicized lawsuit and COX-2 inhibitors fell out of favor, but O’Banion learned a great deal about litigation and the remarkable process of drug development and promotion.

Back in 1990, as a postdoctoral fellow, O’Banion collaborated with a number of other investigators at Rochester who were utilizing 2-dimensional gels to address their own questions. In particular, Kerry worked with Martha Bohn and Paul Coleman, in the Department of Neurobiology and Anatomy, to work respectively on glucocorticoid regulated genes in glial cells and proteins associated with hippocampal death.  Inspired by his grandfather’s bout with fronto-temporal dementia, his previous interest in neurobiology, and an invitation to work in the area of Alzheimer’s disease as a junior investigator with protection under a LEAD Award to Paul Coleman from the National Institute of Aging, Kerry accepted a position as a tenure-track Assistant Professor in the Department of Neurology at Rochester in 1991. Today, he serves as Professor of Neurobiology and Anatomy at the University of Rochester Medical Center.

In the late 80’s and early 90’s several investigators, including Pat McGeer in Vancouver, Joe Rogers in Arizona, and Piet Eikelenboom in the Netherlands, had recognized that classic Alzheimer’s disease pathology included changes in glial cells, particularly microglial cells, that were consistent with local tissue inflammation. In addition, the first studies suggesting that non-steroidal anti-inflammatory drugs might reduce risk for Alzheimer’s disease were just being published. Thus the field was ripe for studies of inflammatory signaling and cyclooxygenases in the context of neurodegeneration. Supported by a series of grants from NIA and NINDS, O’Banion’s contributions in this area included characterization of COX-2 regulation in astrocytes treated with proinflammatory cytokines, quantitative analyses of COX expression in human brain tissues and Alzheimer’s disease, and the effects of aging on inflammation following brain trauma. Past and ongoing studies have examined the role of neuroinflammation, as it has come to be known, in Amyotrophic Lateral Sclerosis, psychiatric disease, learning and memory, and drug abuse.  In addition to a number of extraordinary graduate students, this work was accomplished in close collaboration with John Olschowka who was one of the first to demonstrate interleukin-1 expression in brain.  Indeed, John and Kerry jointly run the “O-labs” for Neuroinflammation Research at the University of Rochester.

Most recently their work has led to a reappraisal of the role of neuroinflammation in Alzheimer’s disease.  Collaborating with Stephanos Kyrkanides, a former graduate student who is now Chair of Orthodontics and Pediatric Dentistry at Stony Brook, O’Banion’s group developed a mouse model of chronic neuroinflammation and addressed a long-standing question about the role of interleukin-1 in Alzheimer’s pathology.  Previous evidence suggested that interleukin-1 should exacerbate Alzheimer’s pathology, but instead, Kerry’s group found that mice overexpressing this proinflammatory cytokine within local brain tissue had reduced amyloid plaque pathology, possibly because of cell recruitment and enhanced phagocytosis. Mechanisms underlying this observation have become an important focus of the laboratory and are being funding by an RO1 grant from the NIA.

But where does radiation and NASA fit into all of this?  In 1997, Phil Rubin and Jackie Williams approached John and Kerry to participate in the renewal of a long-standing CERRIS grant, with a project focused on neuroinflammation in normal tissue injury after radiation. This work showed that COX-2 was an important contributor to the acute neuroinflammatory changes seen following high-dose brain irradiation and led, in 2005, to funding of an RO1 from NCI to examine the acute and late neuroinflammatory effects of radiation in normal brain tissue with a focus on prostaglandin and IL-1 signaling pathways.

O’Banion lab members who have participated in NASA Experiments at Brookhaven National Laboratory are: (left to right) Michael Moravan (MD-PhD Student), Jackie Williams, PhD (Radiation Oncology), Fiona Dubuss (PhD Student), Kerry O’Banion, Michael Wu (MD-PhD Student), Lee Trojanczyk (Technical Associate), and Sean Hurley, PhD.O’Banion’s relationship with NASA started with a meeting with David Tomko arranged by Kerry’s chair, Gary Paige, who had previously worked with NASA on vestibular-ocular reflexes.  David made Kerry aware of the Space Radiobiology Program and encouraged him to apply.   Funded in 2004, O’Banion’s initial project with NASA will provide a description of the acute and long-term (up to 12 months) neuroinflammatory effects of relatively high dose HZE particles in a brain-only exposure mouse model. A follow-up grant initiated last November focuses on the neuroinflammatory and behavioral effects of protons at doses that may be encountered in space. This work is being carried out with whole mouse radiation exposure at NSRL, and includes an examination of systemic effects including a subproject exploring pulmonary inflammation as well as work in an Alzheimer’s mouse model. O’Banion has also successfully competed for funding from the DOE/NASA Low Dose Radiation Program with a grant that focuses on low dose HZE and gamma radiation effects on hippocampal neurogenesis and gene expression. In all of these efforts, Kerry has benefited from an extraordinary team at Rochester that includes Jackie Williams in Radiation Oncology, Sean Hurley (a graduate of the Space Radiation Summer School), Lee Trojanczyk and John Olschowka in Neurobiology, and several outstanding graduate students.  They in turn have benefited from the remarkable support provided by NSRL and the Medical Department at Brookhaven National Laboratories.

Like his educator parents, O’Banion also has a strong commitment to education and training.  For over 10 years he has served as the basic neuroscientist responsible for teaching in the integrated Mind Brain and Behavior Course for second year medical students and shares responsibility with Sean Hurley and John Olschowka for a graduate course on Neuroinflammation that will enter its fourth iteration this coming spring.  Administratively, O’Banion has served as the Director of the Medical Scientist Training Program (MSTP) at Rochester since 2000 and has shepherded the program through three successful grant renewals and an expansion by nearly 100% (to over 60 MD-PhD trainees).  Nationally, Kerry is Chair-Elect of the MD-PhD Section of the AAMC Graduate Research Education and Training (GREAT) Group and serves on the board of the American Physician Scientists Association (APSA).  He also is Director of a Pre- and Postdoctoral Training Grant on Neuroinflammation and Glial Cell Biology awarded by NINDS.

Family plays an important part in Kerry’s life as well.  His 24-year old son Colin completed a BS in Neuroscience at the University of Rochester in 2008, and is currently working as a Lab Manager at Johns Hopkins, investigating cellular therapeutics for ALS.  Colin will be applying to graduate school in Toxicology or Molecular Pharmacology. Kerry’s spouse Dorothy Petrie is an ordained Methodist minister who recently retired as a music teacher working with primary grade levels in the public schools. Kerry and Dorothy get plenty of opportunities to pass along their love of learning to their three grandchildren aged 8, 10 and 13 who live in the Thousand Islands Region of New York.

Selected Publications

M. K. O'Banion, H. B. Sadowski, V. Winn and D. A. Young, A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J Biol Chem 266, 23261-23267 (1991).

M. K. O'Banion, V. D. Winn and D. A. Young, cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci U S A 89, 4888-4892 (1992).

V. D. Winn, M. K. O'Banion and D. A. Young, Anti-inflammatory glucocorticoid action: inhibition of griPGHS, a new cyclooxygenase. J Lipid Mediat 6, 101-111 (1993).

K. A. Pritchard, Jr., M. K. O'Banion, J. M. Miano, N. Vlasic, U. G. Bhatia, D. A. Young and M. B. Stemerman, Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. J Biol Chem 269, 8504-8509 (1994).

J. W. Chang, P. D. Coleman and M. K. O'Banion, Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. Neurobiol Aging 17, 801-808 (1996).

M. K. O'Banion, J. C. Miller, J. W. Chang, M. D. Kaplan and P. D. Coleman, Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J Neurochem 66, 2532-2540 (1996).

M. D. Kaplan, J. A. Olschowka and M. K. O'Banion, Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor. J Biol Chem 272, 18534-18537 (1997).

J. A. Olschowka, S. Kyrkanides, B. K. Harvey, M. K. O'Banion, J. P. Williams, P. Rubin and J. T. Hansen, ICAM-1 induction in the mouse CNS following irradiation. Brain Behav Immun 11, 273-285 (1997).

S. Kyrkanides, J. A. Olschowka, J. P. Williams, J. T. Hansen and M. K. O'Banion, TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury. J Neuroimmunol 95, 95-106 (1999).

M. K. O'Banion, Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit Rev Neurobiol 13, 45-82 (1999).
A. V. Yermakova, J. Rollins, L. M. Callahan, J. Rogers and M. K. O'Banion, Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J Neuropathol Exp Neurol 58, 1135-1146 (1999).

J. W. Chang, D. A. Young, P. D. Coleman and M. K. O'Banion, Two-dimensional gel analysis of secreted proteins induced by interleukin-1 beta in rat astrocytes. Neurochem Int 39, 349-359 (2001).

S. Kyrkanides, M. K. O'Banion, P. E. Whiteley, J. C. Daeschner and J. A. Olschowka, Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J Neuroimmunol 119, 269-277 (2001).

Y. Matsuoka, M. Picciano, B. Malester, J. LaFrancois, C. Zehr, J. M. Daeschner, J. A. Olschowka, M. I. Fonseca, M. K. O'Banion, et al., Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol 158, 1345-1354 (2001).

A. V. Yermakova and M. K. O'Banion, Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol Aging 22, 823-836 (2001).

M. T. Heneka, E. Galea, V. Gavriluyk, L. Dumitrescu-Ozimek, J. Daeschner, M. K. O'Banion, G. Weinberg, T. Klockgether and D. L. Feinstein, Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease. J Neurosci 22, 2434-2442 (2002).

S. D. Hurley, J. A. Olschowka and M. K. O'Banion, Cyclooxygenase inhibition as a strategy to ameliorate brain injury. J Neurotrauma 19, 1-15 (2002).

S. Kyrkanides, A. H. Moore, J. A. Olschowka, J. C. Daeschner, J. P. Williams, J. T. Hansen and M. K. O'Banion, Cyclooxygenase-2 modulates brain inflammation-related gene expression in CNS radiation injury. Mol. Brain Res. 104, 159-169 (2002).

M. K. O'Banion, S. Kyrkanides and J. A. Olschowka, Selective inhibition of cyclooxygenase-2 attenuates expression of inflammation-related genes in CNS injury. Adv Exp Med Biol 507, 155-160 (2002).

S. D. Hurley, M. K. O'Banion, D. D. Song, F. S. Arana, J. A. Olschowka and S. N. Haber, Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys. Exp Neurol 184, 659-668 (2003).

S. S. Shaftel, J. A. Olschowka, S. D. Hurley, A. H. Moore and M. K. O'Banion, COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells. Brain Res Mol Brain Res 119, 213-215 (2003).

A. H. Moore, J. A. Olschowka and M. K. O'Banion, Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain. J Neuroimmunol 148, 32-40 (2004).

A. H. Moore, J. A. Olschowka, J. P. Williams, S. L. Paige and M. K. O'Banion, Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain. Radiat Res 161, 153-160 (2004).

J. J. Hoozemans and M. K. O'Banion, The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs. Curr Drug Targets CNS Neurol Disord 4, 307-315 (2005).

A. H. Moore, J. A. Olschowka, J. P. Williams, P. Okunieff and M. K. O'Banion, Regulation of prostaglandin E2 synthesis after brain irradiation. Int J Radiat Oncol Biol Phys 62, 267-272 (2005).

S. A. Joseph, E. Lynd-Balta, M. K. O'Banion, P. M. Rappold, J. Daschner, A. Allen and J. Padowski, Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures. Neuroscience 140, 1051-1065 (2006).

Y. C. Lai, S. S. Shaftel, J. N. Miller, R. H. Tallents, Y. Chang, C. A. Pinkert, J. A. Olschowka, I. M. Dickerson, J. E. Puzas, M. K. O'Banion, S. Kyrkanides, Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain. Arthritis Rheum 54, 1184-1197 (2006).

M. E. Maida, S. D. Hurley, J. A. Daeschner, A. H. Moore and M. K. O'Banion, Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease. Brain Res 1103, 164-172 (2006).

S. Brouxhon, S. Kyrkanides, M. K. O'Banion, R. Johnson, D. A. Pearce, G. M. Centola, J. N. Miller, K. H. McGrath, B. Erdle, et al., Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism. Cancer Res 67, 7654-7664 (2007).

M. T. Heneka and M. K. O'Banion, Inflammatory processes in Alzheimer's disease. J Neuroimmunol 184, 69-91 (2007).

S. Kyrkanides, P. M. Fiorentino, J. N. Miller, Y. Gan, Y. C. Lai, S. S. Shaftel, J. E. Puzas, M. G. Piancino, M. K. O'Banion and R. H. Tallents, Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint. Arthritis Rheum 56, 2038-2048 (2007).

S. S. Shaftel, T. J. Carlson, J. A. Olschowka, S. Kyrkanides, S. B. Matousek and M. K. O'Banion, Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci 27, 9301-9309 (2007).

S. S. Shaftel, S. Kyrkanides, J. A. Olschowka, J. N. Miller, R. E. Johnson and M. K. O'Banion, Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117, 1595-1604 (2007).

P. M. Fiorentino, R. H. Tallents, J. N. Miller, S. M. Brouxhon, M. K. O'Banion, J. E. Puzas and S. Kyrkanides, Spinal interleukin-1beta in a mouse model of arthritis and joint pain. Arthritis Rheum 58, 3100-3109 (2008).

S. Kyrkanides, A. W. Miller, J. N. Miller, R. H. Tallents, S. M. Brouxhon, M. E. Olschowka, M. K. O'Banion and J. A. Olschowka, Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration. J Neuroimmunol 203, 50-57 (2008).

S. S. Shaftel, W. S. Griffin and M. K. O'Banion, The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J Neuroinflammation 5, 7 (2008).

Z. Zhong, R. Deane, Z. Ali, M. Parisi, Y. Shapovalov, M. K. O'Banion, K. Stojanovic, A. Sagare, S. Boillee, et al., ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci 11, 420-422 (2008).

A. M. Hein and M. K. O'Banion, Neuroinflammation and memory: the role of prostaglandins. Mol Neurobiol 40, 15-32 (2009).

M. K. O'Banion, Prostaglandin E(2) synthases in neurologic homeostasis and disease. Prostaglandins Other Lipid Mediat Apr 22 [Epub ahead of print] (2009).

A. H. Moore, M. Wu, S. S. Shaftel, K. A. Graham and M. K. O'Banion, Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory. Neuroscience In Press.

Space Radiation Investigators’ Recent Publications

Papers in Press

Carra C, Cucinotta FA.
Binding sites of the E coli DNA Recombinase Protein to the ssDNA, a Computational Study.
J Biomol Struct Dynamics 2009 (in press)
(PI: FA Cucinotta)

Kim MY, Hayat M, Feiveson A, Cucinotta FA.
Using high-energy proton fluence to improve risk prediction for consequences of solar particle events
Adv Space Res 2009 (in press)
(PI: FA Cucinotta)

Plante I, Cucinotta FA.
Calculations of the energy deposition and relative frequency of hits of cylindrical nanovolume in medium irradiated by ions by Monte-Carlo tracks structure simulations.
Radiat Env Biophys (in press)
(PI: FA Cucinotta)

Posted in September 2009

Fakir H, Tan WY, Hlatky L, Hahnfeldt P, Sachs RK.
Stochastic population dynamic effects for lung cancer progression.
Radiat Res. 2009 Sep;172(3):383-93.
(PI: L. Hlatky/P. Hahnfeldt/R.K. Sachs/NSCOR)

Fishman K, Baure J, Zou Y, Huang TT, Andres-Mach M, Rola R, Suarez T, Acharya M, Limoli CL, Lamborn KR, Fike JR.
Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD
.
Free Radic Biol Med. 2009 Aug 22. [Epub ahead of print]
(PI: G.A. Nelson/J.R. Fike/NSCOR)

Rithidech KN, Supanpaiboon W, Honikel L, Whorton EB.
Induction of genomic instability after an acute whole-body exposure of mice to 56Fe ions.
Adv Space Res. 2009 Oct 15;44(8):895-906.
(PI: K.N. Rithidech)

Posted in August 2009

Benice TS, Raber J.
Testosterone and dihydrotestosterone differentially improve cognition in aged female mice.
Learn Mem. 2009 Aug;16(8):479-85.
(PI: J. Raber)

Blakely EA, Chang PY. 
Biology of charged particles
Cancer J. 2009 Jul-Aug;15(4):271-84. 
  (PI: E.A. Blakely)

Quigley D, Balmain A.
Systems genetics analysis of cancer susceptibility: From mouse models to humans.
Nat Rev Genet. 2009 Jul 28. [Epub ahead of print]
(PI: A. Balmain)

Wambi CO, Sanzari JK, Sayers CM, Nuth M, Zhou Z, Davis J, Finnberg N, Lewis-Wambi JS, Ware JH, El-Deiry WS, Kennedy AR.
Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival.
Radiat Res. 2009 Aug;172(2):175-86.
(PI: A.R. Kennedy)

Weil MM, Bedford JS, Bielefeldt-Ohmann H, Ray FA, Genik PC, Ehrhart EJ, Fallgren CM, Hailu F, Battaglia CL, Charles B, Callan MA, Ullrich RL. 
Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ions.
Radiat Res. 2009 Aug;172(2):213-9. 
(PI: R.L. Ullrich/NSCOR)

Zhang Y, Zhou J, Baldwin J, Held KD, Prise KM, Redmond RW, Liber HL.  Ionizing radiation-induced bystander mutagenesis and adaptation: Quantitative and temporal aspects.
Mutat Res. 2009 Aug 18. [Epub ahead of print]  

Zhao Y, Sfeir AJ, Zou Y, Buseman CM, Chow TT, Shay JW, Wright WE.
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells.
Cell. 2009 Aug 7;138(3):463-75.
(PI: J.D. Minna/J.W. Shay/W.E. Wright/NSCOR)

Posted in July 2009

Bandstra ER, Thompson RW, Nelson GA, Willey JS, Judex S, Cairns MA, Benton ER, Vazquez ME, Carson JA, Bateman TA.
Musculoskeletal changes in mice from 20-50 cGy of simulated galactic cosmic rays.
Radiat Res. 2009 Jul;172(1):21-9.
(PIs: G.A. Nelson, T.A. Bateman)

Chylack LT Jr, Peterson LE, Feiveson AH, Wear ML, Manuel FK, Tung WH, Hardy DS, Marak LJ, Cucinotta FA. 
NASA Study of Cataract in Astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity.
Radiat Res. 2009 Jul;172(1):10-20.
(PI: L.T. Chylack)

Elmore E, Lao XY, Kapadia R, Redpath JL.
Threshold-type dose response for induction of neoplastic transformation by 1 GeV/nucleon iron ions.
Radiat Res. 2009 Jun;171(6):764-70.
(PI: J.L. Redpath)

Enderling H, Park D, Hlatky L, Hahnfeldt P.
The importance of spatial distribution of stemness and proliferation state in determining tumor radioresponse.
Math Model Natural Phenom. 2009;4(3):117-33.
(PI: L. Hlatky/P. Hahnfeldt/NSCOR)

George KA, Hada M, Jackson LJ, Elliott T, Kawata T, Pluth JM, Cucinotta FA.
Dose response of gamma rays and iron nuclei for induction of chromosomal aberrations in normal and repair-deficient cell lines.
Radiat Res. 2009 Jun;171(6):752-63.
(PIs: J.M. Pluth, F.A. Cucinotta)

Henderson MA, Valluri S, DesRosiers C, Lopez JT, Batuello CN, Caperell-GrantA, Mendonca MS, Powers EM, Bigsby RM, Dynlacht JR.
Effect of gender on radiation-induced cataractogenesis.
Radiat Res. 2009 Jul;172(1):129-33.
(PI: J.R. Dynlacht)

Lin YF, Nagasawa H, Peng Y, Chuang EY, Bedford JS.
Comparison of several radiation effects in human MCF10A mammary epithelial cells cultured as 2D monolayers or 3D acinar stuctures in matrigel.
Radiat Res. 2009 Jun;171(6):708-15.
(PI: J.S. Bedford)

Sudo H, Garbe J, Stampfer MR, Barcellos-Hoff MH, Kronenberg A.
Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation.
Radiat Res. 2008 Jul;170(1):23-32.
(PI: M.H. Barcellos-Hoff/A. Kronenberg/NSCOR)

Tian J, Pecaut MJ, Coutrakon GB, Slater JM, Gridley DS.
Response of extracellular matrix regulators in mouse lung after exposure to photons, protons and simulated solar particle event protons.
Radiat Res. 2009 Jul;172(1):30-41.
(PI: D.S. Gridley)

Yan B, Wang H, Xie D, Wakamatsu N, Anscher MS, Dewhirst MW, Mitchel RE, Chen BJ, Li CY.
Increased skin carcinogenesis in caspase-activated DNase knockout mice.
Carcinogenesis. 2009 Jun 18. [Epub ahead of print]
(PI: C.Y. Li)

Posted in June 2009
Hall EJ
Is there a place for quantitative risk assessment?
J. Radiol Prot. 2009 Jun;29(2):A171-84.
Epub 2009 May 19.
(PI: E.J. Hall)

Kim MH, Hayat MJ, Feiveson AH, Cucinotta FA.
Prediction of frequency and exposure level of solar particle events.
Health Phys. 2009 Jul;97(1):68-81.
(PI: F.A. Cucinotta)

Plante I, Cucinotta FA.
Cross sections for the interactions of 1 eV – 100 MeV electrons in liquid water and application to Monte-Carlo simulation of HZE radiation tracks.
New J Phys. 2009 June 11: 1-24
(PI: F.A. Cucinotta)

Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ.
A new view of radiation-induced cancer: Integrating short- and long-term processes. Part I: Approach.
Radiat Environ Biophys.
2009 Jun 18. [Epub ahead of print]
(PI: L. Hlatky; L. Hlatky/R.K. Sachs/NSCOR)

Villasana L, Rosenberg J, Raber J.
Sex-dependent effects of (56)Fe irradiation on contextual fear conditioning in C57BL/6J mice.
Hippocampus.
2009 Jun 1. [Epub ahead of print]
(PI: J. Raber)

Posted in May 2009
Asaithamby A, Chen DJ.
Cellular responses to DNA double-strand breaks after low-dose {gamma}-irradiation.
Nucleic Acids Res. 2009 Apr 28. [Epub ahead of print]
(PIs: D.J. Chen; J.D. Minna/D.J. Chen/NSCOR)

Benice TS, Raber J.
Dihydrotestosterone modulates spatial working-memory performance in male mice.
J Neurochem. 2009 May 19. [Epub ahead of print]
(PI: J. Raber)

Enderling H, Hlatky L, Hahnfeldt P.
Migration rules: Tumours are conglomerates of self-metastases.
Br J Cancer. 2009 May 19. [Epub ahead of print]
(PI: L. Hlatky/P. Hahnfeldt/NSCOR)

Hei TK, Ballas LK, Brenner DJ, Geard CR.
Advances in radiobiological studies using a microbeam.
J Radiat Res (Tokyo). 2009 Mar;50 Suppl A:A7-A12.
(PI:  CR Geard)

Held KD.
Effects of low fluences of radiations found in space on cellular systems.
Int J Radiat Biol. 2009 May 85(5) 379-390.
  (PI: K.D. Held)

Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S.
EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma.
Cancer Res. 2009 May 15;69(10):4252-9. Epub 2009 May 12.
(PI: S. Burma)

Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA.
RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.
Cancer Res. 2009 May 15;69(10):4107-11. Epub 2009 May 12.
(PI: S. Burma)

Peng Y, Borak TB, Bouffler SD, Ullrich RL, Weil MM, Bedford JS.
Radiation leukemogenesis in mice: Loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma Rays. Part II. Theoretical considerations based on microdosimetry and the initial induction of chromosome aberrations.
Radiat Res. 2009 Apr;171(4):484-93.
(PI: R.L. Ullrich/M.M. Weil/J.S. Bedford/NSCOR)

Peng Y, Brown N, Finnon R, Warner CL, Liu X, Genik PC, Callan MA, Ray FA, Borak TB, Badie C, Bouffler SD, Ullrich RL, Bedford JS, Weil MM. Radiation leukemogenesis in mice: Loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma rays. Part I. Experimental observations.
Radiat Res. 2009 Apr;171(4):474-83.
(PI: R.L. Ullrich/J.S. Bedford/M.M. Weil/NSCOR)

Pujari G, Berni A, Palitti F, Chatterjee A.
Influence of glutathione levels on radiation-induced chromosomal DNA damage and repair in human peripheral lymphocytes.
Mutat Res. 2009 Apr 30;675(1-2):23-8. Epub 2009 Feb 10.
(PI: A. Chatterjee)

Rabin BM, Carrihill-Knoll K, Hinchman M, Shukitt-Hale B, Joseph JA, Foster BC.
Effects of heavy particle irradiation and diet on object recognition memory in rats.
Adv Space Res. 2009 Apr 15;43(8):1193-9.
(PI: B.M. Rabin)

Scuric Z, Chan CY, Hafer K, Schiestl RH.
Ionizing radiation induces microhomology-mediated end joining in trans in yeast and mammalian cells.
Radiat Res. 2009 Apr;171(4):454-63.
(PI: RH Schiestl)

Tomimatsu N, Mukherjee B, Burma S.
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.
EMBO Rep. 2009 May 15. 10 (6) 629-635. [Epub ahead of print]. 
(PI: S. Burma)

Posted in April 2009
Grey M, Goldsten J, Maurer R, Roth D, Zeitlin C.
Data acquisition for the Combined Ion and Neutron Spectrometer (CINS).
Nucl Instrum Methods Phys Res B. 2009 Jan;267(1):139-43.
(PI: R. Maurer)

Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Pecaut MJ.
Low dose, low dose rate photon radiation modifies leukocyte distribution and gene expression in CD4(+) T cells.
J Radiat Res (Tokyo). 2009 Mar;50(2):139-50.
(PI: D.S. Gridley)

Huang L, Smith A, Cummings P, Kendall EJ, Obenaus A.
Neuroimaging assessment of memory-related brain structures in a rat model of acute space-like radiation.
J Magn Reson Imaging. 2009 Apr;29(4):785-92.
(PI: A. Obenaus)

Rithidech KN, Honikel L, Rieger R, Xie W, Fischer T, Simon SR.
Protein-expression profiles in mouse blood-plasma following acute whole-body exposure to (137)Cs gamma rays.
Int J Radiat Biol. 2009 Apr 7:1-16. [Epub ahead of print]
(PI: K.N. Rithidech)

Zeitlin C, Maurer R, Roth D, Goldsten J, Grey M.
Development and evaluation of the Combined Ion and Neutron Spectrometer (CINS).
Nucl Instrum Methods Phys Res B. 2009 Jan;267(1):125-38.
(PI: R. Maurer)

Posted in March 2009
Fakir H, Hofmann W, Tan WY, Sachs RK.
Triggering-response model for radiation-induced bystander effects.
Radiat Res. 2009 Mar;171(3):320-31.
(PI: L. Hlatky/R.K. Sachs/NSCOR)

Fike JR, Rosi S, Limoli CL.
Neural precursor cells and central nervous system radiation sensitivity.
Semin Radiat Oncol. 2009 Apr;19(2):122-32.
(PIs: J.R. Fike, C.L. Limoli)

Ianzini F, Kosmacek EA, Nelson ES, Napoli E, Erenpreisa J, Kalejs M, Mackey MA.
Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe.
Cancer Res. 2009 Mar 15;69(6):2296-304.
(PI: F. Ianzini)

Rice OV, Grande AV, Dehktyar N, Bruneus M, Robinson JK, Gatley SJ.
Long-term effects of irradiation with iron-56 particles on the nigrostriatal dopamine system.
Radiat Environ Biophys. 2009 April; 48(2) 215-225.
(PI: S.J. Gatley)

Williams ES, Klingler R, Ponnaiya B, Hardt T, Schrock E, Lees-Miller SP, Meek K, Ullrich RL, Bailey SM.
Telomere dysfunction and DNA-PKcs deficiency: Characterization and consequence.
Cancer Res. 2009 Mar 1;69(5):2100-7. Epub 2009 Feb 24.
(PI: S.M. Bailey)

Posted in February 2009
Dingfelder M, Travia A, McLawhorn RA, Shinpaugh JL, Toburen LH.
Electron emission from foils and biological materials after proton impact.
Radiat Phys Chem Oxf Engl 1993. 2008;77(10-12):1213-7.
(PI: M. Dingfelder)

Kato TA, Okayasu R, Bedford JS.
Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis.
J Cell Physiol. 2009 June 219(3):760-765. Feb 10. [Epub ahead of print]
  (PI: J.S. Bedford)

Siegel JA, Benice TS, Van Meer P, Park BS, Raber J.
Acetylcholine receptor and behavioral deficits in mice lacking apolipoprotein E.
Neurobiol Aging. 2009 Jan 27. [Epub ahead of print]
(PI: J. Raber)

Xie Y, Wang X, Story M.
Statistical methods of background correction for Illumina BeadArray data.
Bioinformatics. 2009 25:751-757. Feb 4. [Epub ahead of print]
(PIs: J.D. Minna/M. Story/NSCOR; R. Ullrich/M. Story/NSCOR)

Posted in January 2009
Dynlacht JR, Valluri S, Lopez J, Greer F, Desrosiers C, Caperell-Grant A, Mendonca MS, Bigsby RM.
Estrogen protects against radiation-induced cataractogenesis.
Radiat Res. 2008 Dec;170(6):758-64.

Weterings E, Verkaik NS, Keijzers G, Florea BI, Wang SY, Ortega LG, Uematsu N, Chen DJ, van Gent DC.
The Ku80 carboxy-terminus stimulates joining and Artemis-mediated processing of DNA ends.
Mol Cell Biol. March 2009, p. 1134-1142, Vol. 29, No. 5 2008 Dec 22. [Epub ahead of print]
(PI: D.J. Chen)

Posted in December 2008
Rosi S, Andres-Mach M, Fishman KM, Levy W, Ferguson RA, Fike JR.
Cranial irradiation alters the behaviorally induced immediate-early gene Arc (activity-regulated cytoskeleton-associated protein).
Cancer Res. 2008 Dec 1;68(23):9763-70.
(PI: J.R. Fike)

Valtonen M, Nurmi P, Zheng JQ, Cucinotta FA, Wilson JW, Horneck G, Lindegren L, Melosh J, Rickman H, Mileikowsky C.
Natural transfer of viable microbes in space from planets in extra-solar systems to a planet in our solar system and vice-versa.
Astrophys J. 2009 Jan 1;690(1):210-5.
(PIs: J.W. Wilson, F.A. Cucinotta)

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Little JB.
Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation.
Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):909-17.
(PI: DS Gridley)

Posted in November 2008
Acevedo SF, Tittle S, Raber J.
Transgenic expression of androgen receptors improves spatial memory retention in both sham-irradiated and (137)Cs gamma-irradiated female mice.
Radiat Res. 2008 Nov;170(5):572-8.
(PI: J. Raber)

Gaillard S, Pusset D, de Toledo SM, Azzam EI, Fromm M.
Distance distribution of bystander effects in alpha-particle irradiated cell populations using a CR-39-based culture dish.
Radiat Meas. 2008 Aug;43(Suppl.1):S34-40.
(PI: E.I. Azzam)

Lloyd SA, Bandstra ER, Travis ND, Nelson GA, Bourland JD, Pecaut MJ, Gridley DS, Willey JS, Bateman TA.
Spaceflight-relevant types of ionizing radiation and cortical bone: Potential LET effect?
Adv Space Res. 2008 Dec 15;42(12):1889-97.
(PIs: E.R. Bandstra, NASA Graduate Student Researcher Program; G.A. Nelson/NSCOR; T.A. Bateman)

Sawakuchi GO, Yukihara EG, McKeever SW, Benton ER.
Overlap of heavy charged particle tracks and the change in shape of optically stimulated luminescence curves of Al2O3:C dosimeters.
Radiat Meas. 2008 Feb-Jun;43(2-6):194-8.
(PI: E.R. Benton)

Taddei PJ, Zhao Z, Borak TB.
A comparison of the measured responses of a tissue-equivalent proportional counter to high energy heavy (HZE) particles and those simulated using the Geant4 Monte Carlo code.
Radiat Meas. 2008 Oct 17. [Epub ahead of print]
(PI: T.B. Borak)

Posted in October 2008
Calaf GM, Echiburú-Chau C, Zhao YL, Hei TK.
BigH3 protein expression as a marker for breast cancer.
Int J Mol Med. 2008 May;21(5):561-8.
(PI: Y. Zhao)

Dziegielewski J, Baulch JE, Goetz W, Coleman MC, Spitz DR, Murley JS, Grdina DJ, Morgan WF.
WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability
Free Radic Biol Med. 2008 Dec 15 45(12) 1674-1681.  Sep 18. [Epub ahead of print]
(PI: W.F. Morgan)

Maxwell CA, Fleisch MC, Costes SV, Erickson AC, Boissière A, Gupta R, Ravani SA, Parvin B, Barcellos-Hoff MH.
Targeted and nontargeted effects of ionizing radiation that impact genomic instability.
Cancer Res. 2008 Oct 15;68(20):8304-11.
(PI: M.H. Barcellos-Hoff/S.V. Costes/B. Parvin/NSCOR)

Rithidech KN, Scott BR.
Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation.
Dose Response. 2008;6(3):252-71. Epub 2008 May 21.
(PI: KN Rithidech)

Posted in September 2008
Bennett P, Ishchenko AA, Laval J, Paap B, Sutherland BM.
Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells.
Free Radic Biol Med. 2008 Nov 1 45(9) 1352-1359. Aug 14. [Epub ahead of print]
(PIs: B.M. Sutherland, A.M. Gewirtz)

Finnberg N, Wambi C, Ware JH, Kennedy AR, El-Deiry WS.
Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo.
Cancer Biol Ther. 2008 Dec;7(12):2023-33.
(PI: A.R. Kennedy)

Mao JH, Wu D, Delrosario R, Castellanos A, Balmain A, Perez-Losada J.
Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.
Oncogene. 2008 27, 6596-6600 Aug 4. [Epub ahead of print]
(PI: A. Balmain)

Kurpinski K, Jang DJ, Bhattacharya S, Rydberg B, Chu J, So J, Wyrobek A, Li S, Wang D.
Differential effects of X-rays and high-energy (56)Fe ions on human mesenchymal stem cells.
Int J Radiat Oncol Biol Phys. 2009 1 Mar 73(3), 869-877. 2008 Dec 18. [Epub ahead of print]
(PI: D. Wang)

Mukherjee B, Camacho CV, Tomimatsu N, Miller J, Burma S.
Modulation of the DNA-damage response to HZE particles by shielding.
DNA Repair (Amst). 2008 October 7(10), 1717-1730. 2008 Aug 11. [Epub ahead of print]
(PIs: S. Burma; J.D. Minna/S.Burma/NSCOR)

Whalen MK, Gurai SK, Zahed-Kargaran H, Pluth JM.
Specific ATM-mediated phosphorylation dependent on radiation quality.
Radiat Res.2008 Sep;170(3):353–64
(PI: J.M. Pluth)

Posted in August 2008
Hagelstrom RT, Askin KF, Williams AJ, Ramaiah L, Desaintes C, Goodwin EH, Ullrich RL, Bailey SM.
DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals.
Oncogene. 2008 27, 6761-6769. 2008 Aug 4. [Epub ahead of print]
(PI: S.M. Bailey)

Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA, Geard CR.
Mechanism of radiation-induced bystander effects: A unifying model.
J Pharm Pharmacol. 2008 Aug;60(8):943-950.
(PI: E.J. Hall)

Tunquist BJ, Hoshi N, Guire ES, Zhang F, Mullendorff K, Langeberg LK, Raber J, Scott JD.
Loss of AKAP150 perturbs distinct neuronal processes in mice.
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12557-62. Epub 2008 Aug 18.
(PI: J. Raber)

Villasana L, Poage C, van Meer P, Raber J.
Passive avoidance learning and memory of 56Fe sham-irradiated and irradiated human apoE transgenic mice.
Radiats Biol Radioecol. 2008 Mar-Apr;48(2):167-70.
(PI: J. Raber)

Willey JS, Grilly LG, Howard SH, Pecaut MJ, Obenaus A, Gridley DS, Nelson GA, Bateman TA.
Bone architectural and structural properties after (56)Fe(26+) radiation-induced changes in body mass.
Radiat Res. 2008 Aug;170(2):201-7.
(PIs: T.A. Bateman, G. Nelson)

Zhang Y, Rohde LH, Emami K, Hammond D, Casey R, Mehta SK, Jeevarajan AS, Pierson DL, Wu H.
Suppressed expression of non-DSB repair genes inhibits gamma-radiation-induced cytogenetic repair and cell cycle arrest.
DNA Repair (Amst). 7(11) 1 Nov 2008 2008, 1835-1845. Aug 11. [Epub ahead of print]
(NASA Space Radiation Project support)